TRIB2 safeguards naive T cell homeostasis during aging

TRIB2 safeguards naive T cell homeostasis during aging

Blog Article

Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging.Here, we show that echofix spring reverb TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation.TRIB2 deficiency increases AKT activity and accelerates proliferation and differentiation in response to interleukin-7 (IL-7) in humans and during lymphopenia in mice.TRIB2 transcription is controlled by the lineage-determining transcription factors ThPOK and RUNX3.Ablation of Zbtb7b (encoding ThPOK) verona wig and Cbfb (obligatory RUNT cofactor) attenuates the difference in lymphopenia-induced proliferation between naive CD4+ and CD8+ cells.

In older adults, ThPOK and TRIB2 expression wanes in naive CD4+ T cells, causing loss of naivety.These findings assign TRIB2 a key role in regulating T cell homeostasis and provide a model to explain the lesser resilience of CD8+ T cells to undergo changes with age.